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Study on the brain mechanism of down-regulation of cough reflex after stroke

Study on the brain mechanism of down-regulation of cough function after stroke

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400086164
Enrollment
Unknown
Registered
2024-06-26
Start date
2024-07-01
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

Stroke patients group:none
healthy control group:none

Sponsors

The First Affiliated Hospital of Fujian Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Stroke patients: (1) Patients with first cerebral infarction met the diagnostic criteria for ischemic stroke established by WHO; CT/MRI confirmed a unilateral supratentorial lesion in the cerebral hemisphere, right handed (2) Recessive aspiration was confirmed by routine standardized swallowing angiography after stroke (3) Age 18-70 (4) Duration of illness from 14 days to 6 months (5) Can comply with the instructions to cooperate with the inspection (6) The body has no metal implants, and can perform MRI and NIRS examination; (7) With the consent of patients and their families, voluntarily sign informed consent Health control: (1) The subjects sign informed consent and voluntarily participate in the experiment; (2) no history of neuropsychiatric diseases and family history; (3) No history of chronic respiratory diseases (4) Edinburgh Handedness Scale rated as right-handedness

Exclusion criteria

Exclusion criteria: Patient: (1) non-unilateral or subtentorial lesions; (2) Previous history of stroke, brain tumor, brain trauma or other neuropsychiatric; (3) A history of chronic respiratory disease; (4) Previous history of organic neck disease, (5) severe cardiopulmonary and renal complications; (6) can not cooperate with the examination and treatment. (7) Patients with tracheotomy Health control: Pregnant, lactating or menstruating women; Refuse to sign informed consent.

Design outcomes

Primary

MeasureTime frame
Diffusiontensorimage,DTI;Near-infrared functional brain imaging;

Secondary

MeasureTime frame
Cough reflex threshold;

Countries

CHINA

Contacts

Public ContactLV LAN

The First Affiliated Hospital of Fujian Medical University

591981816@qq.com+86 135 5919 5342

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026