Pain
Conditions
Interventions
Lidocaine group:1. Before anesthesia induction: 1.5mg/kg lidocaine intravenous infusion for 10 minutes, the maximum dose does not exceed 100mg
2. After intubation to the end of surgery: Intravenous co
Sufentanil group:1. Before anesthesia induction: intravenous infusion of normal saline of the same volume at a rate of 1.5mg/kg/h for 10 minutes
2. After intubation to the end of surgery: intravenous
Sponsors
Gansu Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients who are scheduled to undergo elective cranial mass resection during general anesthesia; 2. Age 18-65 years old; 3. ASA Grading I- III; 4. Preoperative Glasgow coma score of 15 points; 5. The score of the preoperative Mini-Mental State Examination Scale > 24 points to rule out the influence of preoperative neuropsychological dysfunction.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to the drugs used in the study; 2. History of previous craniotomy, systemic malignancy, diabetes, psychiatric disorder, alcoholism, and drug abuse; 3. Radiotherapy/chemotherapy before or after surgery; 4. Abnormal liver and kidney function, severe cardiopulmonary failure; 5. Body mass index (BMI) 28 kg/cm2; 6. Inability to use the PCIA device or understand the pain VAS score
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain VAS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| S100 beta protein;Neuron specific enolase;Perioperative total opioid consumption ;Mean arterial pressure;Heart rate;Postoperative quality of recovery score;The number of PCIA compressions and the number of effective compressions at 48 hours after surgery;Interleukin-6;Tumor necrosis factor alpha;C-reaction protein;Lidocaine blood concentration; | — |
Countries
China
Contacts
Public ContactYan Wenjun
Gansu Provincial People's Hospital
Outcome results
None listed