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Effect of a subanaesthetic dose of esketamine on etomidate ED50 in elderly patients undergoing painless gastroscopy

Effect of a subanaesthetic dose of esketamine on etomidate ED50 in elderly patients undergoing painless gastroscopy

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400086145
Enrollment
Unknown
Registered
2024-06-26
Start date
2024-07-01
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with painless gastroscopy

Interventions

E1 group:Etomidate

Sponsors

The First Affiliated Hospital of Anhui Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 80 Years

Inclusion criteria

Inclusion criteria: ?Age 65-80 years old, male or female, ASAI ~ III ?Patients who are going to undergo painless gastroscopy, ASAI ~ II ?Body Mass Index (BMI) 18.5-24 kg/m2 ?Can communicate normally Voluntary subjects and signed the informed consent form ?Taking the test and signing the informed consent form voluntarily

Exclusion criteria

Exclusion criteria: ?History of allergy or contraindication to any investigational drugs and anaesthetics; ?Severe cardiac, pulmonary, hepatic and renal abnormalities; ?Patients who are unable to communicate normally; ?Patients with depression, epilepsy, history of psychosis, etc.; ?Long-term use of sedative and analgesic drugs; ?History of smoking or alcohol abuse.

Design outcomes

Primary

MeasureTime frame
Median effective dose of etomidate;Dosage of esketamine used;

Secondary

MeasureTime frame
Pulse Oximetry Saturation;Blood pressure;Recovery time;Repeated dose;Adverse events;Orientation recovery time;

Countries

China

Contacts

Public ContactGuo Peipei

The First Affiliated Hospital of Anhui Medical University

602253956@qq.com+86 199 5519 8661

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026