Alzheimer's disease
Conditions
Interventions
precise localized group:precise localized rTMS
non-precise localized group:non-precise localized rTMS
Sponsors
Hangzhou Normal University
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: Health control group: (1) Age range from 55 to 80 years old; (2) The objective neuropsychological assessment score is within the normal range; (3) No concerns about cognitive decline or cognitive decline; (4) Through MRI safety screening; (5) Has not participated in any other clinical trials recently; (6) Sign the informed consent form for the participants. Cognitive impairment group: (1) Age range from 55 to 80 years old; (2) Clinical dementia rating (CDR) scores range from 2 to 3 points; (3) The score of the Mini Mental State Examination (MMSE) is less than 18 points; (4) Use a stable dose of therapeutic medication for at least 3 months prior to TMS treatment; (5) Through TMS safety screening, DBS electrodes without metal implantation, with no history of epilepsy or other neurological and psychiatric disorders, and no motor system diseases; (6) Through MRI safety screening, with no history of head injury or serious heart disease, and able to complete MRI scans; (7) Has not participated or is currently not involved in other TMS trials; (8) Sign the informed consent form for the participants.
Exclusion criteria
Exclusion criteria: Health control group: (1) Proactively withdraw from the experiment; (2) All fMRI images show head movement, translation>3mm, and rotation>3 °. Cognitive impairment group: (1) There are obvious adverse reactions; (2) Proactively withdraw from the experiment; (3) Those who are unable to determine the efficacy or whose data is incomplete, which affects the judgment of efficacy or safety; (4) All fMRI images show head movement, translation>3mm, and rotation>3 °.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical dementia rating;mini-mental state examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| severe impairment battery, SIB;activity of daily living, ADL;Neuropsychiatric Inventory,NPI;CIBIC-Plus; | — |
Countries
China
Contacts
Public ContactYufeng Zang
Hangzhou Normal university
Outcome results
None listed