cervical spine disease
Conditions
Interventions
Propofol group:Propofol
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1: Elective cervical spine surgery 2: Aged 18-65 years 3: ASA grade I-II 4: BMI 18-29 kg/m2 5: modified Mallampati grade ?-? 6: Patients volunteered to participate in the trial and signed informed consent form
Exclusion criteria
Exclusion criteria: 1: Patients with oropharyngeal masses 2: Patients with contraindications to deep sedation/general anesthesia or a previous history of sedation/anesthesia accidents 3: Patients with known allergies to eggs, soy products, opioids and their antidotes, propofol, and remazolam benzenesulfonate; and persons with contraindications to propofol, benzodiazepines, opioids, and their antidotes; 4: History of severe hepatic, renal, digestive, hematologic, neuromuscular, or metabolic disorders that, in the judgment of the investigator, may increase the risk of sedation/anesthesia and make participation in the study unsuitable 5: Long-term use of analgesics, psychiatric system medications (including opioids, NSAIDs, tranquilizers, antidepressants), alcohol abuse, and a history of chronic pain 6: Patients who have participated in a clinical trial of any drug within 1 month prior to screening; 7: Pregnant and lying-in women 8: Electrocardiogram suggesting: heart rate 120 beats/min 9: Monoamine oxidase inhibiting drugs or antidepressants within fifteen days; 10: Abnormal pulmonary function or admission pulse oximetry of 95% or less 11: Subjects who, in the opinion of the investigator, have any other factors that make participation in this clinical study inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| respiratory rate;SPO2; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Blood pressure;Bispectral index; | — |
Countries
China
Contacts
Public ContactYongzheng Han
Peking University Third Hospital
Outcome results
None listed