postoperative Cognitive Dysfunction
Conditions
Interventions
Intravenous analgesia combined with pericapsular nerve group block analgesia group (P group):Intravenous analgesia pump combined with ultrasound-guided pericapsular nerve group block analgesia
Intravenous analgesia combined with femoral nerve block analgesia group (F group):Intravenous analgesia pump combined with ultrasound-guided femoral nerve block analgesia
Simple intravenous controlled analgesia group (Group C):Intravenous Analgesia Pumps
Sponsors
Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age range from 65 to 90 years old, regardless of gender; 2. Body Mass Index (BMI) is between 18-30kg/m2; 3. The American Society of Anesthesiologists (ASA) classifies of patients is grades I-III. 4. Those who have not been treated with other antidepressants or anxiety medications. 5. The patient and their family members are informed and agree to the study, voluntarily sign the informed consent form and actively cooperate with the clinical study. The process of obtaining the informed consent form should comply with GCP regulations.
Exclusion criteria
Exclusion criteria: 1. ASA greater than Level III; 2. Existence of coagulation dysfunction; 3. Known allergy history to local anesthetics; 4. Puncture site rupture or infection; 5. Congenital lower limb deformities and functional impairments; 6. History of central nervous system diseases and mental illness;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative cognitive function assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum levels of IL-1 ß, IL-6, IL-8, IL-10, TNF - a, CRP, and S-100 ß proteins;sleep condition;Pain assessment;Consumption of analgesic drugs;Remedial analgesia; | — |
Countries
China
Contacts
Public ContactLiu Jie
Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine
Outcome results
None listed