Induction of anesthesia in elderly patients
Conditions
Interventions
Esketamine group:0.2 mg/kg esketamine given at induction of anesthesia
Control group:0.2 mg/kg saline given at induction of anesthesia
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age = 65 years and gender; (2) ASA grade II-III; (3) Patients intended for elective general anesthesia surgery (4) BMI of 20-30 kg/m2; (5) Patients who agreed to be voluntarily enrolled in this trial;
Exclusion criteria
Exclusion criteria: (1) Patients with poorly controlled or uncontrolled hypertension, acute elevation of blood pressure, or risk of increased intracranial pressure; (2) Patients with severe cardiopulmonary, hepatic, or renal dysfunction, psychiatric disorders, neurodegenerative disorders, epilepsy, a history of long-term use of psychotropic medications, and severe cognitive impairment; (3) Patients with allergies to relevant drugs; (4) Patients with adrenocortical insufficiency; (5) Patients with contraindications to esketamine: glaucoma, large hemangiomas, etc. (6) Patients who have recently participated in clinical trials with other drugs; (7) Any condition that, in the opinion of the investigator, makes them unsuitable for enrollment for any reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| heart rate;BIS;cardiovascular event; | — |
Countries
China
Contacts
Public ContactKeliang Xie
Tianjin Medical University General Hospital
Outcome results
None listed