depression
Conditions
Interventions
S group:intraoperative esketamine administration
C group:intraoperative saline administration
Sponsors
HUASHAN HOSPITAL FUDAN UNIVERSITY
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) at the age of 18 to 60 2) BMI = 30 kg/m^2 3) preoperative PHQ-9 score = 5 4) American College of Anesthesiologists (ASA) Grade II~III 5) Laparoscopic sleeve gastrectomy without contraindications 6) the patient has signed an informed consent form
Exclusion criteria
Exclusion criteria: 1) patients who refuse to participate in clinical trials, refuse to sign informed consent forms or participate in other studies in the same period 2) severe neurological lesions (such as epilepsy) 3) have a history of severe respiratory diseases (such as severe asthma, COPD, respiratory dysfunction, etc.) 4) have a history of severe heart disease (such as severe cardiac insufficiency, malignant arrhythmia, etc.) 5) have a history of severe mental illness (such as schizophrenia, severe depression) or a history of drug abuse 6) people who are allergic to conventional anesthetics or have contraindications (propofol, fentanyl, rocuronium, etc.) 7) there are contraindications for esmolamine drugs, such as intracranial hypertension, unstable angina pectoris, heart failure, myocardial infarction, thoracic or abdominal aortic aneurysms, etc. 8) pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient Health Questionnaire-9 items, PHQ-9; | — |
Secondary
| Measure | Time frame |
|---|---|
| Generalized Anxiety Disorder, GAD-7;incidence of PONV ; | — |
Countries
CHINA
Contacts
Public ContactYingwei Wang; Bairu Liu
HUASHAN HOSPITAL FUDAN UNIVERSITY
Outcome results
None listed