High grade squamous intraepithelial lesion, HSIL
Conditions
Interventions
HPV typing and integration detection: Positive HPV integration after HSIL conization:None
HPV typing and integration detection: Negative HPV integration after HSIL conization :None
Sponsors
Shenzhen Maternity and Child Healthcare Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: (1) Patients with initial diagnosis of cervical HSIL and follow-up HPV infection at 6-12 months after conization surgery, as well as those with the same type of infection before surgery; (2) The subjects voluntarily joined this study, signed an informed consent form, had good compliance, and cooperated with follow-up.
Exclusion criteria
Exclusion criteria: (1) Patients with pregnancy; (2) Patients who have been previously diagnosed with cervical HSIL and have undergone standardized surgical treatment; (3) Patients whose first postoperative review of HPV is more than 12 months after surgery; (4) History of malignant tumors in the reproductive system; (5) Patients with severe immune system diseases and active disease; (6) Patients who are unwilling to undergo follow-up 12 months or 24 months after surgery; (7) Refusal to sign informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The cumulative risk of HSIL recurrence at 12 months after surgery in the integrated positive group compared to the integrated negative group; | — |
Secondary
| Measure | Time frame |
|---|---|
| The cumulative risk of HSIL recurrence at 24 months after surgery in the integrated positive group compared to the integrated negative group;the general data ;human papilloma virus (HPV) test;Thinprep cytologic test;Vaginoscopy results; | — |
Countries
China
Contacts
Public ContactPing Jin
Shenzhen Maternity and Child Healthcare Hospital
Outcome results
None listed