Depression
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) Meeting the Diagnostic criteria of DSM-5(Diagnostic and Statistical Manual of Mental Disorders, 5th Edition) for single or recurrent depressive disorder; Signed written informed consent; (2) 60 years old =85 years old, male or female; (3) 7 points < baseline HAMD-17 total score =17 points; (4) Primary school education or above, can complete the assessment ;(5) MoCA=22
Exclusion criteria
Exclusion criteria: (1) People with suicidal thoughts or behaviors; (2) Patients with a history of epilepsy or coronary heart disease or other serious unstable physical diseases; (3) Previous or current DSM-5 diagnosis of any of the following mental disorders: Organic mental disorders, Alzheimer's disease and other causes lead to secondary causes of dementia, schizophrenia, schizoaffective disorder, bipolar disorder, delusional disorders, undifferentiated patients with mental illness, has a history of substance abuse, including with alcohol, and active drug abuse in the past 12 months, except nicotine. (4) Participated in another interventional clinical study within the past month;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD-17 scale score at each follow-up point; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMA scale score at each follow-up point;PSQI scale score at each follow-up point;MADRS scale score at each follow-up point;Eeg data at each follow-up point;GDS scale score at each follow-up point;MMSE scale score at each follow-up point;MOCA scale score at each follow-up point; | — |
Countries
China
Contacts
Beijing Anding Hospital affiliated to Capital Medical University