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A single center prospective clinical study evaluating the effectiveness and safety of ablation strategies for persistent atrial fibrillation based on electrophysiological induction outcomes under sinus rhythm

A single center prospective clinical study evaluating the effectiveness and safety of ablation strategies for persistent atrial fibrillation based on electrophysiological induction outcomes under sinus rhythm

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400086033
Enrollment
Unknown
Registered
2024-06-24
Start date
2024-07-01
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

persistent atrial fibrillation

Interventions

EPS(+) group:DC-EPS AF ablation strategy
EPS(-) group:DC-EPS AF ablation strategy

Sponsors

Sun Yat-sen Memorial Hospital of Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Age range from 18 to 80 years old; (2) Persistent atrial fibrillation confirmed by dynamic electrocardiogram; (3) Voluntarily accept the first radiofrequency ablation treatment and sign the surgical consent form.

Exclusion criteria

Exclusion criteria: (1) Patients with paroxysmal atrial fibrillation; (2) Severe organic heart disease (severe mitral regurgitation, dilated cardiomyopathy, hypertrophic cardiomyopathy, and other severe valvular disease); (3) After combining congenital heart disease or patent foramen ovale and performing occlusion or surgical repair surgery; (4) After artificial valve implantation surgery; (5) Contraindications to systemic anticoagulation; (6) A history of stroke for any reason within 3 months; (7) Have a history of bleeding in the past 30 days or a high risk of bleeding in the past; (8) Platelet count3 x upper limit of maximum limit (ULN); (13) Life expectancy is less than 1 year; (14) Previously implanted any type of pacemaker or after left atrial appendage occlusion surgery; (15) Acute myocardial infarction or PCI within 3 months, with a history of CABG within 6 months; (16) After catheter ablation for previous arrhythmias (including atrial fibrillation); (17) The anterior posterior diameter of the left atrium measured along the long axis of the sternum is = 60mm; (18) Left ventricular ejection fraction<40% or in the decompensated phase of heart failure.

Design outcomes

Primary

MeasureTime frame
The incidence of free of atrial arrhythmias such as atrial fibrillation, atrial flutter, or atrial tachycardia for more than 30 seconds within 1 year after operation;

Secondary

MeasureTime frame
The total procedure time under DC-EPS AF ablation strategy;The fluoroscopy time under DC-EPS AF ablation strategy;Radiofrequency ablation time under DC-EPS AF ablation strategy;

Countries

China

Contacts

Public ContactXie Shuanglun

Sun Yat-sen Memorial Hospital of Sun Yat-sen University

xieshuanglun@sina.com+86 138 2600 5673

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026