Infectious diseases
Conditions
Interventions
Observational group:None
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Admitted to Nanjing Drum Tower Hospital from December 2023 to December 2026; (2) Adult (age = 18 years old) and agree to participate in the study; (3) Clinical diagnosis of bacterial infection with clear indications of bacterial infection; (4) Use piperacillin tazobactam for anti infection treatment.
Exclusion criteria
Exclusion criteria: (1) Due to various reasons, the treatment time of piperacillin tazobactam is less than 72 hours; (2) Severe adverse reactions after the application of piperacillin tazobactam and intolerable treatment Patients; (3) Patients who are unable to monitor blood drug concentration at the designated time due to various reasons; (4) Pregnant, pregnant or breastfeeding patients; (5) Patients undergoing extracorporeal membrane oxygenation; (6) Patients undergoing artificial liver or plasma exchange; (7) After bacterial culture, it was found that the infected bacteria were patients who were resistant to piperacillin and tazobactam; (8) According to the judgment of the research team, there are other patients who are not suitable for participating in this study or may not benefit the subjects from participating in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical efficacy at Day 7; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum concentration of Piperacillin ;Microbial eradication rate at day 7;Length of hospital stay;30-day mortality;Re-admission at Day 30;Area under curve of SIRS score within first week after receiving therapy;Adverse Events; | — |
Countries
China
Contacts
Public ContactDayu Chen
Nanjing Drum Tower Hospital
Outcome results
None listed