breast cancer
Conditions
Interventions
Esketamine group:Esketamine 0.3mg/kg/h was pumped continuously during the operation
Dexmedetomidine group:During the operation, dextrometin was injected continuously with 0.4ug /kg/h
Esketamine combined with dexmedetomidine group:Intraoperatively, dextromete 0.4ug /kg/h and esketamine 0.3mg/kg/h were continuously pumped
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Women undergoing modified radical surgery for breast cancer under elective general anesthesia; 2. Age 18-65 years old; 3.ASA grade I - III; 4.BMI 18-30 kg/m^2; 5. Sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. Preoperative sleep disorder, AIS > 6 or PSQI=10; 2. Long-term use of sedative hypnotic drugs to help sleep before surgery; 3. Patients with communication and understanding disorders (language disorders, mental disorders) who cannot complete the scale test; 4. Preoperative sick sinus syndrome, severe sinus bradycardia (HR < 50 beats/min), atrioventricular block II or above and no pacemaker; 5. Obstructive sleep apnea syndrome, STOP-Bang score =3 points; 6. Severe liver and kidney dysfunction; 7. Patients with serious risk of elevated blood pressure or intracranial pressure; 8. Patients with untreated or undertreated hyperthyroidism; 9. People who are allergic to the drugs involved in this experiment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of sleep disorders in the first three nights after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative sleep structure;Anxiety and depression score;postoperation pain;Postoperative recovery quality;Postoperative adverse events; | — |
Countries
China
Contacts
Public ContactChen Xiuxia
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed