Research on Nutritional Management of ICU Patients with Acute Brain Injury

Effects and Mechanisms of ß-Hydroxy-ß-Methylbutyrate Combined with High-Protein Nutrition in the Intervention of ICU Patients with Acute Brain Injury

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400086023

Enrollment

Unknown

Registered

2024-06-24

Start date

2024-07-01

Completion date

Unknown

Last updated

2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ICU Acute Brain Injury

Interventions

HMB group:HMB supplement

high protein group:High-Protein Diet

combination group:HMB combine high protein

control group:Standard Nutritional Management

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Meets the diagnostic criteria for acute brain injury and has undergone surgical intervention. 2. Age = 18 years. 3. Under mechanical ventilation for more than 24 hours. 4. Patient or family member has given informed consent and voluntarily participates in this study.

Exclusion criteria

Exclusion criteria: 1. Pre-existing neuromuscular diseases, such as amyotrophic lateral sclerosis, myasthenia gravis, Guillain-Barré syndrome, etc. 2. In the terminal stage of a disease. 3. Expected ICU stay < 7 days. 4. Hospital stay = 14 days prior to ICU admission. 5. Combined liver or kidney failure. 6. Presence of limb amputation or other major limb deficiencies.

Design outcomes

Primary

Measure	Time frame
Rectus Femoris Thickness;	—

Secondary

Measure	Time frame
Rectus Femoris Cross-Sectional Area;body composition;Mid-Upper Arm Circumference;Calf Circumference;	—

Countries

China

Contacts

Public ContactTingting Wu

The First Affiliated Hospital of Fujian Medical University

itt2016@126.com+86 152 8010 1510

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026