cholecystectomy
Conditions
Interventions
Desflurane group:The desflurane group continued to inhale desflurane, maintaining an end of breath concentration of 4.5% to 5.5%
sevoflurane group:The sevoflurane group continued to inhale sevoflurane, maintaining an end of breath concentration of 1.0%~2.0%
propofol group:Intravenous infusion of 1% propofol in the propofol group, 4-6 mg/kg/h
Sponsors
Tianjin Nankai Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 79 Years
Inclusion criteria
Inclusion criteria: The age range is between 65 and 79 years old, with ASA grades ranging from grade I to grade II. The preoperative Mini Mental State Examination (MMSE) score for cognitive function is 27-30 points. There were no serious complications related to hypertension, coronary heart disease, diabetes and other diseases in the past, the cardiopulmonary function was basically normal, there was no history of basic mental disease, and the informed consent of patients and their families was obtained
Exclusion criteria
Exclusion criteria: Concomitant mental illness, epilepsy, Parkinson's disease, myasthenia gravis, severe snoring, upcoming cranial surgery, combined with severe heart problems, combined with severe liver and kidney diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| interleukin-6;Central nervous system specific protein(S100ß);MMSE score for cognitive function assessment;Wake up eye opening time;Directional force recovery time;Postoperative chills;nausea and vomiting;move restlessly;Bronchospasm; | — |
Countries
China
Contacts
Public ContactYu Jianbo
Tianjin Nankai Hospital
Outcome results
None listed