liver cancer
Conditions
Interventions
OF group:esketamine-based opioid-free anesthesia
RA group:conventional opioid anesthesia
Sponsors
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Patients undergoing elective general anesthesia for laparoscopic partial hepatectomy, including hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and metastatic carcinoma; (2) Aged 18-70 years old; (3) ASA physical status I–III; (4) BMI 18-30kg/m2; (5) Clearly understand and voluntarily participate in the study, and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Inability to provide informed consent and communication difficulties; (2) Relevant drug allergies; (3) Patients with severe cardiopulmonary disease or craniocerebral injury and mental illness; (4) Contraindications for esketamine use including a risk for serious rise in blood pressure or intracranial pressure, high intraocular pressure (glaucoma), poorly controlled hypertension (resting systolic blood pressure greater than 180mmHg or resting diastolic blood pressure greater than 100 mmHg), untreated/undertreated hyperthyroidism; (5) History of chronic pain or opioid abuse; (6) Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamic indicators (SBP, DBP, MAP, HR);Cardiovascular active drug dosage;Incidence of cardiovascular adverse events; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS score;analgesic drug consumption;incidence of adverse reactions;HAD;MMSE; | — |
Countries
China
Contacts
Public ContactYang Chun
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital)
Outcome results
None listed