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Application value of DNA gene methylation markers in triage of HPV-positive patients in cervical cancer screening in Northwest China

Epigenomic multi-omics research on the pathogenesis of cervical cancer in Northwest China and clinical application

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400085973
Enrollment
Unknown
Registered
2024-06-21
Start date
2024-07-03
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Uterine Cervical Lesions

Interventions

Training group:None
Validation group:None

Sponsors

People’s Hospital of Ningxia Hui Autonomous Region
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
35 Years to 64 Years

Inclusion criteria

Inclusion criteria: 1. Females aged 35-64 years with a history of sexual life. 2. The initial hrHPV DNA test in the clinic is positive, and the remaining cell samples for hrHPV testing can be collected. 3. Sign the informed consent form, be willing and able to accept colposcopy, and have histological results that meet the diagnostic criteria, if needed. 4. No history of cervical cancer and precancerous lesions treatment.

Exclusion criteria

Exclusion criteria: 1. Pregnant women; 2. Women with immunodeficiency; 3. Women with a history of other gynecological malignancies and tumors; 4. Women with incomplete personal information: sample collection unit, name, age, cytology test results, HPV test results, colposcopy pathology results, cytology history within 5 years, and history of colposcopy within 5 years.

Design outcomes

Primary

MeasureTime frame
DNA methylation;Diagnosis proportion of CIN2+;

Secondary

MeasureTime frame
Diagnosis proportion of CIN3+;

Countries

China

Contacts

Public ContactYang Fan

People’s Hospital of Ningxia Hui Autonomous Region

yangf0803@126.com+86 180 1731 6053

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 17, 2026