Laparoscopic nephrectomy
Conditions
Interventions
normocapnia group:NA
Permissive hypercapnia:NA
Sponsors
Xiangyang Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age 18-70 years old; ASA grade ?-?; Patients undergoing surgery under general anesthesia; Patients voluntarily submit to clinical trials.
Exclusion criteria
Exclusion criteria: A state of shock or coma; Have a history of psychiatric illness and long-term use of psychotropic drugs; Cognitive dysfunction; Pregnant or lactating women; A history of drug dependence; Used other sedatives and analgesics in the last week; Have participated in drug clinical trials as a subject within the last 3 months; Any patient with contraindications to lidocaine, ropivacaine, midazolam, Sufentanil, cisatracurium, tropisetron, propofol, diclofenac sodium, chronic pain. The patient had severe lung disease before surgery, which affected normal ventilation function. The carbon dioxide was higher than 65mmHg during exclusion. SPO2 cannot be maintained above 90%; It was difficult to maintain the airway peak lower than 30cmH2O. Intraoperative blood loss exceeds 20% of blood volume; During the operation, laparotomy was required. Preoperative cognitive impairment, visual and hearing impairment. MMSE scale score is less than 24 points. Preoperative patients with moderate to severe anemia (Hb 5h.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oxygenation index;cerebral oxygen saturation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative cerebral deoxygenation events (CDE): relative decrease of cerebral oxygen saturation from base value =20% or absolute value of rSO2 =55%;Summary mental status Examination (MMSE) and Montreal Cognitive Assessment (MoCA), stress stress Score (SAS) were performed the day before surgery and 3 and 7 days after surgery.; T0: before anesthesia induction; T1: Just start the operation; T2: 30 min after pneumoperitoneum; T3: 60 min after pneumoperitoneum T4: 120 min after pneumoperitoneum (cerebral oxygen saturation, lactic acid (Lac), blood glucose level, PaO2/FIO2 ratio and alveola-arterial oxygen partial pressure gradient (AaDO2));Urinary protein, creatinine and blood uric acid were measured before and 1 day after surgery;Postoperative headache, dizziness, nausea and vomiting, agitation, hypotension, hypertension, hypoxemia; | — |
Countries
China
Contacts
Public ContactZhangxiaodong
Xiangyang Central Hospital
Outcome results
None listed