Cardiovascular disease
Conditions
Interventions
Treatment group:Treatment group: Xidan granules+Western medicine basic treatment
Chinese medicine prescription name: Xidan granules
Drug composition: 10g of American ginseng and 30g of Salvia miltiorr
control group:Control group: placebo granules+Western medicine basic treatment
Placebo granules: mainly composed of dextrin+5% traditional Chinese medicine, with the same appearance and odor as Xidan
Sponsors
Dongfang Hospital of Beijing University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Meets the diagnostic criteria for acute myocardial infarction; (2) Confirmed by coronary angiography and treated with PCI within 24 hours; (3) Patients with TCM syndrome types of Qi deficiency and blood stasis; (4) Age range from 18 to 75 years old; (5) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Acute complications of PCI (cardiac shock, ventricular fibrillation and other malignant arrhythmias after cardiopulmonary resuscitation, valve prolapse caused by chordae/papillary muscle rupture, heart rupture, coronary perforation, pericardial tamponade, as well as sustained IABP assistance for cardiogenic shock, sustained pacemaker assistance for severe bradycardia, and sustained heart failure that cannot be relieved by medication); (2) The patient's blood pressure is difficult to control, with systolic blood pressure = 180mmHg or diastolic blood pressure = 110mmHg; (3) Patients with severe liver and kidney dysfunction (alanine aminotransferase = 1.5 times the normal value, serum creatinine = 194.5 µ mol/L), serum potassium level = 5.5 mmol/L, or with severe endocrine diseases (such as hyperthyroidism, hypothyroidism, diabetes with severe complications); (4) Patients with severe consumption status, primary diseases of the blood system, malignant tumors, etc; (5) Newly diagnosed intracerebral hemorrhage patients within 6 months; (6) The patient has experienced a new bleeding event or trauma within the past month, or is currently suffering from a confirmed active gastrointestinal ulcer disease; (7) Suspicious or clear allergy to the investigational drug; (8) The patient is in pregnancy or lactation, or there may be a pregnancy planner during the follow-up period of this study; (9) Patients with mental illness or infectious diseases; (10) Participants in other clinical studies within the past month; (11) Traditional Chinese medicine syndrome differentiation combined with deficiency cold syndrome or excess cold syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular systolic function change rate (? LVEF); | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac ultrasound related indicators;Related indicators of angina pectoris;Traditional Chinese Medicine Syndrome Points and Therapeutic Effects;Quality of life indicators;Serological indicators; | — |
Countries
the People's Republic of China
Contacts
Public ContactQuan Lin
Dongfang Hospital of Beijing University of Traditional Chinese Medicine
Outcome results
None listed