CKD1-3 stage
Conditions
Interventions
Test group:Alendronate sodium + calcium carbonate D3+ calcitriol capsules
Control group:calcium carbonate D3+ calcitriol capsules
Sponsors
Xijing Hospital affiliated to Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Obtain written informed consent; 2. Age 18-80 years old; 3. Meet the staging standards of KDOQI guidelines for CKD1-3 stages; 4. Receiving glucocorticoid treatment for >6 months, prednisone dose >7.5mg/d or taking other hormones of equivalent price;
Exclusion criteria
Exclusion criteria: 1. Received anti-bone resorption drugs in the last 6 months; 2. History of primary hyperparathyroidism, hyperthyroidism, hypothyroidism, or parathyroidectomy; 3. severe malnutrition; 4. Active infection; 5. Serious lesions of heart, liver, lung and other vital organs; 6. History of multiple myeloma or bone tumor; 7. Allergy to alendronate sodium; 8. Pregnant and lactating women; 9. Previous history of major upper digestive tract (GI) disease, such as peptic ulcer, esophagitis, or severe dyspepsia; 10. Inability to stand or sit upright for more than 30 minutes; 11. Relevant biochemical indicators or bone biopsies suggest low-transport bone disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BMD; | — |
Secondary
| Measure | Time frame |
|---|---|
| BMD;bone metabolism indicators;The incidence of new fractures (non vertebral fractures and clinical vertebral fractures) within 18 months; | — |
Countries
China
Contacts
Public ContactLijie He
Xijing Hospital affiliated to Air Force Medical University
Outcome results
None listed