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To explore the intervention effect and mechanism of Tongdu Tiaoshen acupuncture on vascular cognitive impairment from inflammatory factors activated by HMGB1 expression

To explore the intervention effect and mechanism of Tongdu Tiaoshen acupuncture on vascular cognitive impairment from inflammatory factors activated by HMGB1 expression

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400085923
Enrollment
Unknown
Registered
2024-06-21
Start date
2024-06-28
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vascular cognitive impairment

Interventions

Acupuncture group:Besides the control group, Tongdu Tiaoshen acupuncture was also given.once a day, for 2 months.
Control group:Donepezil 5 mg orally, once a day, for 2 months.

Sponsors

The Second Affiliated Hospital of Anhui University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: ? The diagnosis was consistent with the diagnostic criteria of vascular cognitive impairment in Tian Jinzhou's "Chinese Guidelines for the Diagnosis of Vascular Mild Cognitive Impairment" in 2016; Age: 50~80 years old; ? Gender is not limited; ? Dominant stroke events occurred, and the course of disease was 0-3 months before enrollment; (5) The MMSE score was 16-26 points, and the MoCA score was 19-25 points; ? Clear mind, generally good condition, can cooperate with examination and treatment; ? Patients were enrolled voluntarily and signed the treatment consent

Exclusion criteria

Exclusion criteria: ? There is no correlation between cognitive function impairment and brain function impairment. There was no history of stroke or Transient ischemic attack (TIA) before the onset of the disease. ? Complicated with serious damage to other organs; ? Patients who are unable to complete cognitive tests due to motor, sensory or language disorders.

Design outcomes

Primary

MeasureTime frame
MMSE (mini mental status exam);MoCA(Montreal Cognitive Assessment);CDR (Clinical Dementia Rating);SDSD(Dementia syndrome classification scale);inflammatory factor;HMGB1;pSrc;

Secondary

MeasureTime frame
Security detection;Risk factors related indicators of cerebrovascular disease;

Countries

China

Contacts

Public ContactBal Lin

The Second Affiliated Hospital of Anhui University of Chinese Medicine

515822508@qq.com+86 139 5692 7118

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026