Liver transplantation
Conditions
Interventions
1:Split under hypothermic and normothermic machine perfusion
2:Conventional liver transplantation under static cold storage
Sponsors
Ningbo medical center Lihuili Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Donor Inclusion Criteria: (1) Age = 50 years; (2) Weight = 50 kg; (3) Body Mass Index (BMI) = 25 kg/m²; (4) Hemodynamically stable or on a single vasoactive medication with a minimal dose, norepinephrine = 0.1 ug/kg/min; (5) Liver function indicators (ALT, AST, or total bilirubin quantification) all less than twice the normal value; (6) Serum sodium = 160 mmol/L. Recipient Inclusion Criteria: (1) Graft to recipient weight ratio (GRWR) = 1.0%; (2) No portal vein or mesenteric vein thrombosis; (3) No severe vascular anomalies.
Exclusion criteria
Exclusion criteria: Donor Exclusion Criteria: (1) Complex vascular or biliary variations; (2) Liver obtained from DBD (Donation after Brain Death); (3) Fatty liver proportion > 10%; (4) Confirmed bloodstream infection; (5) Hepatitis B infection; (6) Pathological GS grading, S = Grade 2. Recipient Exclusion Criteria: (1) Model for End-Stage Liver Disease (MELD) score = 30; (2) Re-transplantation of the liver; (3) History of more than one previous liver surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recipient survival rate;Graft survival rate;The incidence of biliary complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function; | — |
Countries
China
Contacts
Public ContactCaide Lu
Ningbo medical center Lihuili Hospital
Outcome results
None listed