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Data-driven modeling analysis of the brain function-gastrointestinal hormone-microflora axis mechanism of "harmonizing and centralization" theory in the treatment of simple obesity

Data-driven modeling analysis of the brain function-gastrointestinal hormone-microflora axis mechanism of "harmonizing and centralization" theory in the treatment of simple obesity

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400085908
Enrollment
Unknown
Registered
2024-06-20
Start date
2024-07-01
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

simple obesity

Interventions

Acupoint embedding group:Acupoint embedding, treatment course: 1 time /2 weeks, 3 times for 1 course of treatment. A total of 8 weeks (the menstrual period of female patients was suspended, and the ti
Nutrition management group:Mainly guided by the academic thought of "harmony to the middle", combined with the differentiation of the patients constitution, the patients life style guidance, diet, exe

Sponsors

Huaibei People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 58 Years

Inclusion criteria

Inclusion criteria: (1) Meet the diagnostic criteria of simple obesitys; Weight: Broca method: Standard body mass = [(height -100cm*0.9(kg)], with body mass exceeding 20% of standard body mass as the standard for obesity. Among them, 20% to 30% of body weight exceeding standard body weight is mild obesity, 30% to 40% of body weight exceeding standard body weight is moderate obesity, and more than 50% of body weight exceeding standard body weight is severe obesity. Body Mass Index (BMI) Body mass (kg)/height (?), referring to the "Redefinition and Treatment of Obesity in the Asia-Pacific Region" guidance manual published in 2000, 23kg/m2=BMI< 24.9kg/? is overweight, BMI=25.0 kg/m2 is obese. Fat percentage F% : body fat percentage (%)= body fat/body mass *100%. Obesity: female =30%. People who meet 2 or more of the above three items and exclude secondary obesity caused by other reasons (pituitary disease, endocrine disease, etc.) can be diagnosed with simple obesity.(2) Age 18-58 years old, gender is not limited; (3) Voluntarily accept various acupuncture treatment and cooperate with various tests, and can cooperate with the entire treatment process, and all patients sign informed consent for treatment.

Exclusion criteria

Exclusion criteria: (1) Patients with secondary obesity; (2) Patients with diabetes, major organic diseases such as heart, brain, liver and kidney, infectious diseases, blood system diseases, and mental diseases; (3) have received Chinese and western medicine treatment related to this disease within one month; (4) patients with critical illness who are difficult to accurately evaluate the effectiveness and safety of this treatment; (5) For some reason, the treatment is not accepted or completed according to the provisions, and the efficacy cannot be judged or the data is incomplete; (6) Poor compliance, can not adhere to the treatment; (7) Pregnant and lactating women. (8) Patients with MRI contraindications.

Design outcomes

Primary

MeasureTime frame
Head MRI brain function analysis;Intestinal flora analysis;Ghrelin ;Leptin;Glucagon-like peptide-1;

Secondary

MeasureTime frame
Body composition analysis;

Countries

China

Contacts

Public ContactLi Xiaomin

Huaibei People's Hospital

lxmyu1226@126.com+86 561 304 2095

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026