emergence agitation
Conditions
Interventions
control:50 mg of flurbiprofen ester is administered intravenously, followed by 5 ml of normal saline.
2.5 mg Remimazolam:Flurbiprofen 50 mg is administered intravenously, followed by 2.5 mg of Remimazolam
5.0 mg Remimazolam:Flurbiprofen 50 mg is administered intravenously, followed by 5.0 mg of Remimazolam
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-65 years; (2) 18.5 kg/m2 = BMI < 30 kg/m2; (3) ASA classification I-III; (4) Patients who recover in the recovery room after general anesthesia; (5) SAS score = 5 after extubation; (6) SPO2 = 90% can be maintained by breathing air or less than 2L/min oxygen inhalation after extubation; The patient must sign an informed consent form before the operation.
Exclusion criteria
Exclusion criteria: (1) Patients who are allergic to benzodiazepines, flumazenil, or flurbiprofen axetil, or have contraindications to these drugs; (2) Patients with dementia or any degree of cognitive impairment; (3) Patients with schizophrenia, bipolar disorder, or other psychiatric disorders; (4) Patients with difficult airways; (5) Patients with obstructed upper airway; (6) Surgery duration = 4 hours; (7) Female patients who tested positive for pregnancy screening or baseline pregnancy test and lactating women; (8) Patients who received benzodiazepine treatment for insomnia or anxiety prior to surgery; (9) Patients who tested positive for substance abuse screening or had a positive baseline alcohol test; (10) Patients with a history of drug abuse within the past 2 years or alcohol dependence; (11) Patients who participated in other drug or device studies within the past 30 days; (12) Patients who participated in any other clinical trial involving ramazolam; (13) Patients who cannot communicate effectively in spoken language.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate for treatment of emergency agitation; | — |
Countries
China
Contacts
Public ContactWang Liwei
Xuzhou Central Hospital
Outcome results
None listed