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Clinical Application Study on Orthodontic Alveolar Bone Augmentation Based on High Osteoinductive Activity Materials

Clinical Application Study on Orthodontic Alveolar Bone Augmentation Based on High Osteoinductive Activity Materials

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400085900
Enrollment
Unknown
Registered
2024-06-20
Start date
2024-06-24
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

During orthodontic treatment, some patients need to undergo significant labiolingual movement of the anterior teeth. Patients with pre-existing alveolar bone defects in the anterior teeth, due to the thin morphology of the soft and hard tissues around these teeth, are prone to exacerbating the original bone defects (bone fenestration, bone dehiscence) during the orthodontic process. Commonly, issu

Interventions

Anterior teeth labial movement Bio-Oss group:Bone augmentation surgery on the labial side of the anterior teeth using Bio-Oss material
Anterior teeth labial movement Rebone bone powder group:Bone augmentation surgery on the labial side of the anterior teeth using Rebone bone material
Anterior teeth lingual movement Bio-Oss group:Bone augmentation surgery on the lingual side of the anterior teeth using Bio-Oss material
Anterior teeth lingual movement Rebone bone powder group:Bone augmentation surgery on the lingual side of the anterior teeth using Rebone bone material

Sponsors

Peking University Hospital of Stomatology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1.The alveolar bone of the upper or lower anterior teeth is thin (the thickness of the bone on the labial and lingual sides is 3mm or labial movement of the anterior teeth >2mm; 3.Anterior teeth and periodontium must be in a healthy state; 4. Adult patients (18-40 years old), regardless of gender;

Exclusion criteria

Exclusion criteria: 1.Participated in another clinical trial within 3 months prior to the start of this trial; 2.Patients with moderate to severe periodontitis; 3.Presence of impacted or missing teeth in the anterior region; 4.Patients who are currently receiving, or have received within the last 3 months, treatment with drugs that may affect or promote bone metabolism; 5.Various bone defects arising from active infectious lesions or active phases of metabolic bone diseases; 6.Patients with severe heart, liver, or kidney dysfunction; 7.Patients with mental disorders lacking the capacity for autonomous behavior; 8.Patients with an allergic constitution; 9.Pregnant or lactating women, and those planning for pregnancy within six months;

Design outcomes

Primary

MeasureTime frame
Alveolar bone morphological indicators;

Secondary

MeasureTime frame
Periodontal clinical indicators;Periodontal soft tissue indicators;Indicators related to the speed of tooth movement;

Countries

China

Contacts

Public ContactWeiran Li

Peking University Hospital of Stomatology

weiranli@bjmu.edu.cn+86 10 82195332

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026