major depressive disorder
Conditions
Interventions
Exercise plus drugs:1. 150 min/ week, 3 to 5 times/week, heart rate reaching 64% to 76% of the maximum heart rate (220 times /min- age), light to moderate aerobic exercise for 3 months
2. 150mg dose o
Drug group:150mg dose of venlafaxine
Exercise group:150 min/ week, 3 to 5 times/week, heart rate reaching 64% to 76% of the maximum heart rate (220 times /min- age), light to moderate aerobic exercise for 3 months
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Ages 18-55; 2. Patients diagnosed with depressive disorder in the outpatient department (according to the DSM-V diagnostic criteria for depressive disorder), mild to moderate depression degree, Hamilton Depression Scale -21 score 7-24; 3. Exercise habits: sit still and do less than 60 minutes of aerobic exercise per week; 4. Native Chinese speaker, sign informed consent.
Exclusion criteria
Exclusion criteria: 1. mental disorders including schizophrenia, bipolar disorder, major depression with suicidal tendencies, alcohol or other substance abuse; 2. Diseases of the nervous system, cardiovascular diseases, lung diseases, endocrine system and other diseases that cannot be intervened in exercise; 3. Have participated in another clinical trial related to exercise or weight management or have family members who have participated in this trial; 4. Taking medications that affect heart rate and blood pressure; 5. Medical history of physical conditions that are not suitable for exercise, such as asthma, arthritis, gout, rheumatoid disease, back knee pain, cancer, Crohn's disease, etc.; 6. Cannot exercise for 30 minutes; Patients with contraindications to antidepressants; 7. Severe impairment of visual, auditory and cognitive functions and eye diseases; 8.BMI greater than 35 or less than 18; 9. Breastfeeding, pregnancy, or pregnancy planning during the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain network connectivity;Brain-heart interaction; | — |
Countries
China
Contacts
Public ContactYang Yuan
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed