inherited thrombophilia
Conditions
Interventions
Hereditary Thrombophilia Group:NA
Sponsors
Fujian Maternity and Child Health Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: (1) Antithrombin deficiency (<30%); (2) Protein C deficiency (<30%); (3) Protein S deficiency (<30%); (4) Women with thrombophilia during pregnancy and family members; (5) The subjects voluntarily participated in this study and signed the informed consent form; (6) Core family members (at least one child and one parent diagnosed with VTE) or non-core family members (the proband and their siblings diagnosed with VTE); (7) No anticoagulant medication used.
Exclusion criteria
Exclusion criteria: (1) Women with anatomical genital anomalies clearly diagnosed by ultrasound or hysterosalpingography; (2) Couples or embryos with chromosomal abnormalities; (3) Women with a history of taking teratogenic drugs early in pregnancy; (4) Systemic or localized immune abnormalities of the reproductive tract (e.g., antiphospholipid syndrome); (5) Malignant tumor; (6) Blood disorders: Autoimmune hemolytic anemia (AIHA), paroxysmal nocturnal hemoglobinuria (PNH), heparin-induced thrombocytopenia (HIT), etc; (7) Recent history of blood transfusion (less than 3 months ago).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gene associated with thrombophilia;venous thromboembolism; | — |
Secondary
| Measure | Time frame |
|---|---|
| abortion;prematurity;Smaller than gestational age;pre-eclampsia;eclampsia;HELLP syndrome;abruption of the placenta;stillbirth; | — |
Countries
China
Contacts
Public ContactZhang Jinhua
Fujian Maternity and Child Health Hospita
Outcome results
None listed