A study on the effect of applying various bone grafting materials in alveolar ridge preservation

A multi-center randomized controlled clinical study of micro crestal flap–alveolar ridge preservation using variable bone graft materials in teeth with severe periodontitis

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400085863

Enrollment

Unknown

Registered

2024-06-20

Start date

2024-10-29

Completion date

Unknown

Last updated

2024-11-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

extraction of teeth with severe periodontitis

Interventions

Alloplast Material Group:micro crestal flap - alveolar ridge preservation

Allograft Material Group:micro crestal flap - alveolar ridge preservation

Xenograft Material Group:micro crestal flap - alveolar ridge preservation

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.Patient is in good general health or well-controlled hypertension and diabetes mellitus; 2.Good oral hygiene and compliance; 3.The presence of teeth that need to be extracted due to severe periodontal disease: PD > 6mm, AL = 5mm, imaging shows that alveolar bone resorption is more than 1/2 of the root length or more, furcation lesions in multiple teeth, and loosening of the teeth > II°; implant prosthetic prosthetics will be considered after the tooth is extracted; 4.Presence of bone defects in the alveolar fossa of the affected teeth with at least two bone walls = 3 mm in height; 5.Presence of at least one adjacent tooth;

Exclusion criteria

Exclusion criteria: 1) Patients 70 years of age; 2) Smoking = 10 cigarettes/day. 3) Pregnant or lactating women. 4) History of head and neck radiation therapy. 5) Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, tetracycline, bisphosphonates, or other drugs that affect bone regeneration. 6) Significant crowding, ectopia, or torsion of the teeth. 7) Acute infection of the affected teeth. 8) Gingival hyperplasia.

Design outcomes

Primary

Measure	Time frame
Three-dimensional changes in soft and hard tissue contours;Alveolar bone height and width changes;	—

Secondary

Measure	Time frame
Histological examination of bone tissue blocks;Bone augmentation procedure during implant surgery;Evaluation of patient's response after surgery;Duration of surgery;Health economics evaluation;	—

Countries

China

Contacts

Public ContactWenjie Hu

Peking University Hospital of Stomatology

huwenjie@pkuss.bjmu.edu.cn+86 10 82195368

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026