Helicobacter pylori infection
Conditions
Interventions
Group A (Experimental Group):Vonolasan 20 mg bid + amoxicillin 1 g tid with multiple administration
Group B (control group):Esomeprazole 20mg bid + Bismuth potassium citrate 220mg bid + amoxicillin 1g bid + clarithromycin 0.5g bid with multiple administration
Sponsors
Mianyang Central Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: The included patients should meet the following conditions at the same time: (1) elderly patients aged > 60 years old and < 75 years old, (2) positive 13/14C rapid urease breath test or Helicobacter pylori antibody test positive and not treated for eradication, (3) meet the indications for HP eradication recommended in the Fifth National Consensus Report on the Treatment of Helicobacter Pylori Infection, (4) outpatients and inpatients, and (5) sign informed consent.
Exclusion criteria
Exclusion criteria: Patients who meet any of the following conditions are excluded from this study. (1) Patients with malignant tumors or gastric ulcers, (2) those who have undergone previous gastric surgery, (3) those who are not willing to participate in the study, (4) those who have had previous cephalosporin allergy or other adverse reactions and cannot tolerate them, (5) those who have had a history of liver and kidney insufficiency, (6) patients who have used any antibacterial drugs, proton pump inhibitors, bismuth agents, and traditional Chinese medicines alone or in combination in the first two weeks of treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 13/14C rapid urease breath test;Symptomatic remission; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events; | — |
Countries
China
Contacts
Public ContactXinhua Zhao
Mianyang Central Hospital
Outcome results
None listed