Disorder of consciousness
Conditions
Interventions
control group:Only traditional rehabilitation treatment was performed.
DBS treatment group :The DBS Surgical Treatment and Regulation Group
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Meet the diagnostic criteria of consciousness disorder; 2) 18-75 years old, regardless of gender; 3) The duration of illness must be more than 3 months, and the consciousness has not been progressively improved or deteriorated for more than 4 weeks; It is suggested that the operation time should be extended to 6 months after injury, and the patient has been unconsciously improved for 8 weeks; 4) The heart, lungs, liver and kidney functions are basically normal; 5) At least one side of the cerebral cortex structure is relatively intact, and the brain stem structure is seriously damaged; 6) Appropriate evaluation (neuroimaging, EEG, various evoked potentials); 7) Expected survival time: > 3 months; 8) can cooperate to observe adverse events and curative effects; 9) No serious surgical contraindications; 10) Imaging examination showed no moderate or above white matter lesions or multiple subcortical lacunar infarcts, no cortical lesions, and no subcortical lesions with a diameter of more than 1-5mm; 11) The pregnancy test of female patients is negative; 12) Blood coagulation function is normal; 13) The legal representative of the patient signs a written informed consent.
Exclusion criteria
Exclusion criteria: 1) Do not meet the diagnosis of chronic disturbance of consciousness (DOC); 2) neurodegenerative diseases, intracranial infection, and coma after brain tumor surgery; 3) The consciousness has been continuously improved or deteriorated within one month before joining the group; 4) those with serious complications; 5) Patients who have participated in other clinical trials within three months before the trial; 6) Patients with severe allergic history or allergic constitution; 7) Pregnancy and lactation; 8) Other serious medical diseases or serious uncontrollable infections; Can cooperate to observe adverse events and curative effect; 9) drug addicts, drug abusers, long-term alcoholics and AIDS patients; 10) Patients or their legal representatives cannot sign written informed consent; 11) Can't cooperate to observe adverse events and curative effect.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CRS-R scale;Scalp EEG;CM-Pf nucleus’s LFP; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient CT and MRI;Patient's blood test results; | — |
Countries
China
Contacts
Public ContactYi Yang
Beijing Tiantan Hospital, Capital Medical University
Outcome results
None listed