Postoperative Cognitive Dysfunction
Conditions
Interventions
CPF group:In the group of cypofol, 0.4 mg/kg was injected intravenously during induction, and 1.0~1.5 mg·kg-1·h-1 was injected intravenously with ciprofol for anesthesia maintenance.
PPF group:The control group was injected with 1.5 mg/kg propofol intravenously during induction, and was injected with 4~12 mg·kg-1·h-1 by intravenous pump during anesthesia maintenance.
Sponsors
Zhongda Hospital, Medical School, Southeast University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: Age = 65 years, ASA class II-III, elective surgery, duration of surgery > 2h.
Exclusion criteria
Exclusion criteria: Preoperative delirium, a score of <15 on the Modified Mental State Examination (MMSE), severe visual or hearing impairment or inability to communicate with the visitor for other reasons, severe heart, lung, liver or kidney disease, history of psychoneurological disorders, or history of psychotropic medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Cognitive Function 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative Cognitive Function 1 month after surgery;Postoperative Cognitive Function 3 months after surgery;Postoperative Cognitive Function 6 months after surgery;Postoperative Cognitive Function 1 year after surgery;postoperative delirium; | — |
Countries
China
Contacts
Public ContactBin Li
Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast University
Outcome results
None listed