Major Depressive Disorder
Conditions
Interventions
transcranial alternating current stimulation (tACS) group:The tACS group was given tACS real stimulation for 2 weeks, 5 times a week, and each stimulation lasted 20 minutes.
temporal interference (TI) group:The TI group was given TI real stimulation for 2 weeks, 5 times a week, and each stimulation lasted 20 minutes.
sham group:The sham group was given sham stimulation for 2 weeks, 5 times a week, and each stimulation lasted 20 minutes.
Sponsors
Tianjin Anding Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria for "depressive disorders" in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), and all patients must have their diagnosis independently confirmed by at least two attending physicians or psychiatrists of higher level, and are currently in a depressive episode; (2) Age 18-50 years old; (3) Gender is not limited; (4) Junior high school education or above; (5) No antidepressant medication used at least 2 weeks before enrollment; (6) Patients can read and understand the informed consent form, self-assessment scale, etc.; (7) Patients or their family members agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Those with a history of psychiatric genetic disorders consistent with DSM-5, or a diagnosis of other mental illnesses other than "depressive disorders"; (2) Those with craniocerebral trauma or a history of coma; (3) Those with organic brain or severe physical diseases; (4) Those with a history of epileptic seizures or a family history of epilepsy; (5) Those with obvious suicidal or impulsive behavior; (6) Those who have received physical therapy such as electroconvulsive therapy and transcranial magnetic stimulation therapy in the past six months; (7) Those with a history of alcoholism or use of other psychoactive substances; (8) Those who are currently participating in other drug clinical trials; (9) Any factors that prevent participants from providing informed consent or participating in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale (HAMD-17) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale (HAMA) score;Young Mania Rating Scale (YMRS) score;Patient Health Questionnaire-9 (PHQ-9) score;Generalized Anxiety Disorder (GAD-7) score;Hypomania Checklist (HCL-32) score; | — |
Countries
China
Contacts
Public ContactShenLi
Tianjin Anding Hospital
Outcome results
None listed