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Endocrine Therapy-related Metabolic Dysfunction and Cardiovascular Adverse Effects in Postmenopausal Breast Cancer

Relationship between endocrine therapy-related metabolic dysfunction and new onset major adverse cardiovascular events and cardiotoxicity in postmenopausal breast cancer patients

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400085814
Enrollment
Unknown
Registered
2024-06-19
Start date
2024-07-01
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postmenopausal breast cancer

Interventions

Divide into a study group and a control group based on whether major cardiovascular outcomes have occurred:NA

Sponsors

The First Affiliated Hospital of Dalian Medical University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: ( 1 ) Breast cancer patients diagnosed for the first time in the First Affiliated Hospital of Dalian Medical University from January 2011 to December 2018 and in Qilu Hospital of Shandong University ( Qingdao ) from January 2014 to December 2018. ( 2 ) Postmenopausal breast cancer patients. ( 3 ) Endocrine therapy, including or not including any chemoradiotherapy and targeted therapy, is included in the treatment plan developed by clinicians for patients according to the National Comprehensive Cancer Network ( NCCN ). ( 4 ) Case information is completely stored in the electronic medical record research database of the corresponding center and collected in a desensitization manner.

Exclusion criteria

Exclusion criteria: ( 1 ) The tumor stage was IV or no detailed evaluation was performed to determine the clinical stage of the tumor. ( 2 ) The diagnosis of breast cancer with other parts of the solid tumors or hematological tumors. ( 3 ) Endocrine therapy drugs have been used before the diagnosis of breast cancer. ( 4 ) Loss of follow-up. ( 5 ) Serious incomplete / missing data.

Design outcomes

Primary

MeasureTime frame
blood pressure;serum glucose;high density lipoprotein-cholesterol;triglyceride;body mass index;heart failure;acute coronary syndrome;stroke;cardiac death;endocrine therapy;

Secondary

MeasureTime frame
low density lipoprotein-cholesterol;alanine aminotransferase;radiotherapy;chemotherapy;surgery;

Countries

China

Contacts

Public ContactYunlong Xia

The First Affiliated Hospital of Dalian Medical University

yunlong_xia@126.com+86 180 9887 5555

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026