Patients with general anesthesia tracheal intubation
Conditions
Interventions
Group L (Lidocaine Group): 2% Lidocaine inhalation nebulization group,: 2% Lidocaine inhalation nebulization
Group D (Dexmedetomidine Group): Dexmedetomidine inhalation nebulization group,:Dexmedetomidine inhalation nebulization
Group LD (Lidocaine-Dexmedetomidine Group): Lidocaine combined with Dexmedetomidine inhalation nebulization group.:Lidocaine combined with Dexmedetomidine inhalation nebulization
Sponsors
Department of Anesthesiology, Huizhou Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ?Patients undergoing laparoscopic cholecystectomy surgery with an American Society of Anesthesiologists (ASA) physical status classification of I to II;?Age between 18 to 65 years old;?No anticipated difficulty with intubation based on preoperative assessment, and good visibility of the laryngeal structures during intubation (Cormack-Lehane grading I to II);?Patients undergoing orotracheal intubation under general anesthesia and have obtained written consent from the patient and their family;?Good patient compliance and ability to cooperate with the relevant examinatio
Exclusion criteria
Exclusion criteria: ?Blood pressure =180/110 mmHg in a calm state upon entering the room;?Diseases such as pulmonary infection, bradycardia, conduction block, arrhythmia, and abnormalities in liver and kidney function;?Difficulty in verbal communication;?Allergies to all relevant medications;?Predicted difficult airway;?History of dependence on alcohol, sedatives, analgesics, etc.;?Body Mass Index (BMI) > 30 kg/m^2, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood Pressure:systolic blood pressure (SBP), diastolic blood pressure (DBP);Heart Rate(HR);Pulse Oximetry (SPO2);Serum Levels of Blood Glucose (Glu);Cortisol (COR);Airway Peak Pressure/The Peak Airway Pressure (Ppeak);Airway Plateau Pressure/The Plateau Airway Pressure(Pplat);Airway Resistance(Raw);Pulmonary Dynamic Compliance (Cdyn) ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Preoperative sedation score;Anesthesia onset time;Dosage of general anesthesia;The occurrence of cardiovascular adverse reactions during induction; | — |
Countries
china
Contacts
Public ContactZhou Wendan
Huizhou Sixth People's Hospital
Outcome results
None listed