Rectal cancer
Conditions
Interventions
Gold Standard:A pathological response (pCR) is diagnosed by an experienced pathologist according to the surgical specimen.
Index test:A pathological response (pCR) is predicted by a deep learning model that has been constructed in our previous work.
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age = 18 years old, pathologically confirmed as rectal adenocarcinoma or mucinous adenocarcinoma; (2) Diagnosed as locally advanced rectal cancer (clinical TNM stage II/III); (3) All patients received neoadjuvant therapy (total neoadjuvant treatment, conventional neoadjuvant chemoradiotherapy, or neoadjuvant chemotherapy) followed by total mesorectal resection (4) Baseline high-resolution pelvic MRI obtained, including T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and apparent diffusion coefficient (ADC) (5) Receive radical surgery and have a complete pathology report; (6) Postoperative pathological response confirmed by an experienced pathologist, including pathologic complete (pCR) and non-pathologic complete (non-pCR); (7) Signed written informed consent.
Exclusion criteria
Exclusion criteria: (1) History of concurrent malignancy or chemoradiotherapy; (2) Patients who do not complete neoadjuvant therapy according to the protocol; (3) Patients who have not undergone radical surgical or not obtain the pathological response evaluation of surgical specimens; (4) No baseline MRI or poor MRI image quality.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve;Accuracy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity;Positive predictive value;Negative predictive value; | — |
Countries
China
Contacts
Public ContactXin Wang
West China Hospital of Sichuan University
Outcome results
None listed