post stroke aphasia
Conditions
Interventions
SLT group:Only receive SLT treatment
Memantine+SLT group:Receive memantine + SLT
Sponsors
Beijing Boai Hospital, China Rehabilitation Research Center
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria were: (1) age between 18 and 70 years, (2) unilateral cortical-subcortical or subcortical lesions caused by a single infarction or hemorrhage diagnosed as stroke by CT/MRI, (3) aphasia diagnosis according to the Western Aphasia Battery (WAB), Fluency =6 was classified as non-fluency aphasia. (4) presence of aphasia for 4 weeks to 6 months prior to the Screening visit, (5) Patients and caregivers are given written informed consent to participate in this trial. (6) Native Chinese (7) Right handedness (8) Junior high school education or above (9) Clear awareness and ability to cooperate with treatment (10) Patient and agent have signed informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria were: (1) Presence of a severe language deficit, (2) history of any other neurological or psychiatric disease impairing language and communicative ability, (3) severe visual agnosia,(4) severe limb apraxia and severe speech apraxia , (5) severe depression,(6) epilepsy,(7) pregnancy, (8) recent myocardial infarction, (9) uncompensated congestive heart failure, (10) uncontrolled hypertension, (11) hypersensitivity toward memantine, (12) ongoing medication with agents interfering with memantine (including amantadine, dextromethorphan, or ketamine).Any concomitant medication was kept unchanged during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WAB-AQ; | — |
Secondary
| Measure | Time frame |
|---|---|
| MMSE;Spontaneous speech -AQ;Auditory comprehension -AQ;Repeating -AQ;Naming -AQ; | — |
Countries
CHINA
Contacts
Public ContactLuping Song
Beijing Boai Hospital, China Rehabilitation Research Center
Outcome results
None listed