none
Conditions
Interventions
Experimental group 1:Lactobacillus plantarum HFY15*14 days
Experimental group 2:Lactobacillus plantarum PL15A*14 days
Experimental group 3:Lactobacillus plantarum H6*14 days
Experimental group 4:Lactobacillus acidophilus LA-10A*14 days
Experimental group 5:Lactobacillus reuteri LR09*14 days
Experimental group 6:Bifidobacterium longum BL300*14 days
Experimental group 7:Bifidobacterium breve BB05*14 days
Sponsors
The First People's Hospital of Kunshan
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Natural persons aged 18-45 years old, controlling sex at about 1:1; 2. Have not taken antibiotics within one month, and have not taken products containing probiotics within half a month; 3. Those who have not suffered from gastrointestinal diseases within one month; 4. Local subjects, no business trips; 5. Voluntarily participate in this trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women, allergic constitution; 2. Patients with serious diseases and endocrine diseases such as cardiovascular, cerebrovascular, liver, kidney and hematopoietic system, and psychosis; 3. Those who have taken antibiotics within one month or foods related to probiotics within 14 days, which affects the judgment of the results; 4. Subjects who other investigators deem unsuitable to participate in this trial, as well as subjects participating in other clinical trials. 4. Other researchers think that they are not suitable to participate in this trial, as well as subjects participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The colonization time of the strain in the subject's intestine;Microbiota analysis(QPCR and Metagenome sequence); | — |
Secondary
| Measure | Time frame |
|---|---|
| Bristol Stool Form Scale;Gastrointestinal Symptom Rating Scale, GSRS; | — |
Countries
China
Contacts
Public ContactXu Yihui
The First People's Hospital of Kunshan
Outcome results
None listed