ARDS
Conditions
Interventions
Control Group:Prone position ventilation
Intervention Group:Nitric oxide inhalation combined with prone position ventilation
Sponsors
Subei People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients aged between 18 and 80 years old, with moderate to severe ARDS within 3 days of onset, meeting the 2012 Berlin diagnostic criteria, having an oxygenation index less than 150 mmHg, and undergoing mechanical ventilation via endotracheal intubation.
Exclusion criteria
Exclusion criteria: (1) Patients with severe asthma or acute exacerbation of chronic obstructive pulmonary disease, lung cancer, lung resection, and post-lung transplant surgery; (2) Patients with hemodynamic instability requiring vasoactive drugs for maintenance: using dopamine, dobutamine > 15µg/kg/min, norepinephrine > 0.3ug/kg/min; (3) Cardiogenic pulmonary edema; (4) Patients with severe facial deformities, facial trauma, or severe chest and abdominal trauma who are unable to undergo prone position ventilation; (5) Patients in the middle to late stages of pregnancy; (6) Patients with a history of malignant tumors or other irreversible diseases/conditions, terminal patients; (7) Patients expected to be discharged shortly or receiving invasive mechanical ventilation for less than 24 hours; (8) Patients currently participating in other studies. The experimental protocol has been approved by the ethics committee, and the patients or their authorized representatives have signed the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PaO2/FiO2; | — |
Secondary
| Measure | Time frame |
|---|---|
| ventilator free days druing 28 days;ICU hospitalization time;28 day mortality rate; | — |
Countries
China
Contacts
Public ContactXiaoyan Wu
Subei People's Hospital
Outcome results
None listed