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Establishment of new clinical classification of acute-on-chronic liver failure and optimization of treatment strategy

Establishment of new clinical classification of acute-on-chronic liver failure and optimization of treatment strategy

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400085780
Enrollment
Unknown
Registered
2024-06-18
Start date
2024-06-20
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute-on-chronic liver failure

Interventions

Different new clinical classification of ACLF:None

Sponsors

Beijing You'an Hospital Affiliated to Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1)Age and gender: 16 to 70 years old (including 16 and 70 years old), regardless of gender; (2)Meet the APASL diagnostic criteria: acute liver injury in patients with chronic liver disease, characterized by jaundice (serum total bilirubin [TBIL]) = 5 mg/dL) and coagulation dysfunction (prothrombin activity [PTA] <40%), and ascites and/or hepatic encephalopathy within 4 weeks; (3)Sign the informed consent.

Exclusion criteria

Exclusion criteria: (1)Liver cancer and other malignant tumors; (2)There are serious chronic diseases of extrahepatic organs: severe chronic obstructive pulmonary disease with respiratory failure, severe coronary heart disease with heart failure, myocardial infarction within 3 months before admission, serious complications of diabetes, chronic kidney failure; (3)Pregnant and lactating women (4)Mental illness

Design outcomes

Primary

MeasureTime frame
The incidence of clinical features with different classification;Mortality rate within 4 weeks+liver transplantation rate;Recovery rate within 4 weeks;Mortality rate within 12 weeks+liver transplantation rate;Recovery rate within 12 weeks;—

Secondary

MeasureTime frame
Total bilirubin;Prothrombin activity, PTA;White blood cell count;Hemoglobin;Platelet count;Prothrombin time;International standardized ratio;Albumin;Urea nitrogen;Blood creatinine;Blood ammonia;Blood oxygen saturation;Lactic acid;Serum viral markers;X-ray chest/chest CT;Abdominal ultrasound/CT/MRI;Alanine aminotransferase;glutamic oxaloacetic transaminase;Blood sodium;Blood potassium;28 day mortality rate of ACLF patients;3-month mortality rate of ACLF patients;6-month mortality rate of ACLF patients;—

Countries

China

Contacts

Public ContactYu Chen

Beijing You'an Hospital Affiliated to Capital Medical University

chybeyond1071@ccmu.edu.cn+86 10 8399 7000

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026