General anesthesia maintenance in elderly patients undergoing gastrointestinal tumor surgery
Conditions
Interventions
Group R:Continuous infusion of remazolam besylate during surgery, anesthesia maintenance, intervention group
Group P:Continuous infusion of propofol during surgery, maintained anesthesia, control group
Sponsors
Beijing Shijitan Hospital,Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age 65 and above; (2) American Society of Anesthesiologists (ASA I-III); (3) Patients undergoing gastrointestinal tumor surgery with elective general anesthesia (intravenous anesthesia) and tracheal intubation; (4) Informed consent, voluntary participation in the experiment, and signing of an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Heart function level 3 or above; Severe liver and kidney disease (Child grade C, patients undergoing renal replacement therapy) (2) Patients undergoing surgery for other systemic tumors; (3) Patients undergoing multimodal anesthesia methods such as compound spinal anesthesia; (4) Patients who are known to be allergic to remazolam benzenesulfonate or benzodiazepines; (5) Patients with abnormal coagulation function, endocrine disorders, or other factors affecting hemodynamic status; (6) Short surgery time (surgery duration<4 hours); (7) Preoperative mental illness (Parkinson's disease, senile dementia), various reasons such as hearing and vision, and inability to fully communicate with others; (8) Patients with a history of drug and alcohol dependence; (9) Subjects deemed unsuitable by the researchers to participate in this study; (10) Participants in other clinical trials within the three months prior to being selected for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative recovery time for patients (defined as the period from the end of surgery to the recovery of consciousness, spontaneous breathing, and removal of tracheal catheters); | — |
Secondary
| Measure | Time frame |
|---|---|
| awakening quality;Record anesthesia induction time, awakening time, PACU/ICU residence time, surgical time, fluid intake and output, dosage of anesthetic and vasoactive drugs, and incidence of intraoperative hypotension (mean arterial pressure below 65mmHg, or a decrease of more than 20% from baseline);Using the Montreal Cognitive Assessment Scale (MoCA) to assess cognitive function 1 day before surgery (T0) and 1-3 days after surgery;Short CAM and ICU-CAM were used to evaluate the incidence of delirium at 1 day (T6), 2 days (T7), and 3 days (T8) after surgery;Use Visual Analog Scale (NRS) to evaluate the patient's sleep and pain levels 1 day before surgery and 1-3 days after surgery;Record hospitalization time and incidence of adverse events (pain, nausea and vomiting, allergies, respiratory depression, hypotension, delayed awakening, etc.); | — |
Countries
China
Contacts
Public ContactZhang Jing
Beijing Shijitan Hospital,Capital Medical University
Outcome results
None listed