Orthotopic liver transplantation
Conditions
Interventions
Bispectral index Group:BIS team: Monitor BIS and MAC simultaneously, BIS guided anesthesia depth management, BIS value maintained at 40-60, MAC only record.
Minimal Alveolar Concentration Group:MAC group: Both BIS and MAC were monitored, the depth of anesthesia was managed by MAC guided, MAC was maintained between 0.7-1.3, and BIS only recorded.
Sponsors
The First Hospital of Jilin University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Middle-aged patients, aged 18-65 years old, ASAII~ Grade III, who intend to undergo orthotopic liver transplantation in our hospital, voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: Patients with existing/acute hepatic encephalopathy (grade II-IV), history of multiple organ transplantation, history of mental illness, history of stroke, history of postoperative delirium or postoperative cognitive impairment, long-term use of drugs that can affect the central nervous system, MELD score > 20, preoperative renal replacement therapy, neurological disease, and refusal to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative opioid consumption;Extubation time;Sevoflurane consumption;Intraoperative awareness incidence;Post-operative pain scoring;Satisfaction scores;The incidence of post-operative adverse events; | — |
Countries
China
Contacts
Public ContactSong Xuesong
The First Hospital of Jilin University
Outcome results
None listed