The clinical study on the effect of low-carbohydrate high-fat nutrient and probiotic intervention in sepsis-induced acute lung injury

The protective effect and mechanistic study of low-carbohydrate high-fat nutrient and probiotic intervention in sepsis-induced acute lung injury

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400085745

Enrollment

Unknown

Registered

2024-06-18

Start date

2024-06-28

Completion date

Unknown

Last updated

2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

LCHF diet+Probiotics:Low carbohydrate high fatty-acid enterial nutrition (Supportan) + Probiotics

LCHF diet+Placebo:Low carbohydrate high fatty-acid enterial nutrition (Supportan) + Placebo

Conventional diet+Probiotics:Conventional enterial nutrition (Nutricia) + Probiotics

Conventional diet+Placebo:Conventional enterial nutrition (Nutricia) + Placebo

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Age=18 2. Diagnosed as sepsis (SOFA=2) 3. Diagnosed as ARDS 4. ICU hospitalization 5. Provided informed consent

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Diagnosed as HIV 3. End-stage malignancy 4. Expected less than 24h survival time 5. Recruited in another conventional clinical trial

Design outcomes

Primary

Measure	Time frame
Oxygenation index;	—

Secondary

Measure	Time frame
Days of ICU stay;Days of Mechanical Ventilation;Murray score of lung injury;	—

Countries

China

Contacts

Public ContactZhiming Xiang

The Affliated Panyu Central Hospital of Guangzhou Medical School

xiangzhiming@pyhospital.com.cn+86 20 3485 8239

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026