total knee replacement
Conditions
Interventions
opioid group:Combination application of opioids for anesthesia and postoperative analgesia protocols
Opioid-free group:Opioid-free general anesthesia and postoperative analgesic protocols
Sponsors
Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) 18 years old <= age <= 80 years old; 2) ASA grade I-III; 3) Type of surgery: adult patients undergoing elective unilateral knee replacement under general anesthesia; 4) BMI of 18.5~30 kg/m^2 [BMI=Weight (Kg) /Height (m) ^2]. 5) Ethical, voluntary and informed consent.
Exclusion criteria
Exclusion criteria: 1) History of undergoing general anesthesia for surgery within one month prior to surgery; 2) Coexisting severe systemic diseases of the cardiovascular, pulmonary, and cerebral systems, such as hypertension, coronary heart disease, COPD, asthma, respiratory failure, pulmonary hypertension, severe cardiac arrhythmias (atrial fibrillation, second-degree or higher atrioventricular block, sick sinus syndrome, etc.), severe valvular heart disease, heart failure, renal failure, stroke and myocardial infarction within the past 6 months, Alzheimer's disease, Parkinson's disease, mental illness, OSAS, myasthenia gravis, etc.; 3) History of chronic pain in other parts of the body; 4) Patients with impaired liver or kidney function; 5) Patients with a history of allergy to the drugs used in this study; 6) Patients with a history of opioid abuse and use of opioid drugs within the past two weeks; 7) Abnormal coagulation function; 8) Patients with METs<4; 9) Patients who refuse or are unable to participate in this study; 10) Patients who participated in another study within the past 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Quality of Recovery Score (QoR-15); | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative Quality of Recovery Score (QoR-15);hemodynamic parameter;IoC Awareness Injury Index; | — |
Countries
China
Contacts
Public ContactJunde Han
Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed