Pulmonary nodules ,Bullae
Conditions
Interventions
E-sketamine group :Induction:0.2mg/kg iv
Maintain:0.2mg/ kg.h-1
Control group:Normal saline
Sponsors
Qujing City First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Patients undergoing thoracoscopic surgery, (2) The age of admission was 18-65 years old, (3) ASA grade I-III, (4) Non-intubation VATS elective operations include: lung wedge resection, segmental resection, partial resection, lobectomy, unilateral radical resection of lung cancer, (5) Patients who are willing to use controlled intravenous analgesia (PCIA), (6) Planned postoperative hospitalization >48 hours, (7) Voluntary signing of informed consent.
Exclusion criteria
Exclusion criteria: (1) Sinus bradycardia or atrioventricular block were complicated before operatio, NYHA cardiac function grade III or above, (2) Severe lung disease (FEV1/FVC30kg/m 2, (4) Allergy to narcotic drugs (including E-sketamine, ropivacaine and lidocaine), (5) Patients with severe consciousness disorder or mental system diseases (schizophrenia, mania, bipolar disorder, etc.) and cognitive dysfunction, (6) difficult airway, (7) A history of chemical therapy, a history of radioactive exposure, the use of corticosteroids and non-steroidal anti-inflammatory drugs within the past month, (8) History of chronic pain and analgesic drugs, (9) Patients with poor preoperative blood pressure control (systolic blood pressure =160mmHg or diastolic blood pressure =110mmHg when sitting; Systolic blood pressure =90mmHg) when sitting, (10) Patients with poor preoperative blood glucose control (random blood glucose =11.1mmol/L), (11) Patients with severe renal dysfunction before surgery (serum creatinine Cr=1.5×ULN), Patients with severe abnormal liver function before operation (aspartate transferase AST or alanine transferase ALT=1.5×ULN; Total bilirubin TBIL=1.5×ULN), (12) History of lung diseases such as bronchiectasis, lung abscess, and tuberculosis that require lung isolation, (13) Pleural adhesion, pulmonary surgical history, coagulation dysfunction (prothrombin time PT extended beyond the upper limit of normal for 3 seconds or activated partial thrombin time APTT extended beyond the normal value for 10 seconds), platelet abnormalities (< 50X109/L) and other possible major bleeding during the operation, (14) Pregnant or lactating patients, (15) Patients with any of the following contraindications for the use of E-sketamine injection: a. Patients at risk for elevated intracranial pressure; b. Patients with high intraocular pressure (glaucoma) or penetrating ocular trauma; c. Untreated or undertreated hyperthyroidism (hyperthyroidism), (16) Patients who are expected to enter the ICU with tubes or return to the ward, (17) The patient refused.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial and venous blood gas analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale; | — |
Countries
China
Contacts
Public ContactDiaofeng Zhang
Qujing City First People's Hospital
Outcome results
None listed