A randomized controlled study of different modalities of transcranial magnetic stimulation in the treatment of autism spectrum disorder

Standard and Demonstration application of rehabilitation intervention for autistic children: a randomized controlled study of different modes of transcranial magnetic stimulation for autism spectrum disorder

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400085735

Enrollment

Unknown

Registered

2024-06-17

Start date

2024-06-30

Completion date

Unknown

Last updated

2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism spectrum disorder

Interventions

rTMS group:The left dorsolateral prefrontal area was stimulated using repetitive transcranial magnetic stimulation at 1Hz

iTBS group:The left dorsolateral prefrontal area was stimulated using intermittent Theta-burst stimulation

cTBS group:The left dorsolateral prefrontal area was stimulated using continuous Theta-burst stimulation

sham group:Patients can hear the sound produced during TMS intervention with a sham stimulation, but the magnetic field of the target is close to 0, the cerebral cortex is not affected by the pulsed m

Eligibility

Sex/Gender

All

Age

2 Years to 18 Years

Inclusion criteria

Inclusion criteria: Patients with autism spectrum disorder admitted to China Rehabilitation Research Center and diagnosed by DSM-V assessment are in stable condition and can cooperate to complete relevant assessment and training; Meet the following requirements: ? Age 2-18 years old; No gender limitation; ?The education level is not limited; ? Subject's parents or legal guardians agree to participate in the study and sign the informed consent with a detailed understanding of the study.

Exclusion criteria

Exclusion criteria: ? Current or past psychotic disorders, including schizophrenia, schizoaffective disorder, bipolar disorder, etc.; ? Serious self-injury or suicide behavior in the past year; ? Patients with severe visual, hearing, deaf-mute or movement disorders who cannot cooperate with examination and treatment; ? Patients with a history of epilepsy and a family history of epilepsy; ? Patients with serious organic diseases, such as congenital heart disease, craniocerebral injury, and significantly increased intracranial pressure; ? Received TMS, transcranial electrical stimulation, transcranial focused ultrasound and other neuroregulatory treatment within 3 months before admission; ? There are metal implants in the skull; ? Those who are undergoing other clinical trials; ? Patients or their families do not agree to receive treatment/examination.

Design outcomes

Primary

Measure	Time frame
Autism Behavior Checklist;Childhood Autism Rating Scale;	—

Secondary

Measure	Time frame
Social responsiveness scale;Autism Treatment Assessment Scale;Functional Near Infrared Spectroscopy;electroencephalogram;	—

Countries

China

Contacts

Public ContactHao Zhang

China Rehabilitation Research Center

crrczh2020@163.com+86 137 0135 6685

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026