The Impact of Different Administration Methods of Dyclonine on Postoperative Throat Pain after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400085725

Enrollment

Unknown

Registered

2024-06-17

Start date

2024-06-24

Completion date

Unknown

Last updated

2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative throat pain following laparoscopic gynecological surgery

Interventions

Group SW:The anesthetic induction is preceded by buccal administration of dyclonine, while also applying dyclonine to the tracheal tube.

Group SP:Before anesthesia induction, dyclonine is administered buccally, and dyclonine is evenly sprayed over the glottis and subglottis.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for elective laparoscopic gynecological surgery; 2. Age 18 to 65 years; 3. Body Mass Index (BMI) 20 to 30 kg/m^2; 4. American Society of Anesthesiologists (ASA) classification I or II; 5. Mallampati airway classification I or II; 6. Patients voluntarily participate in this study, sign an informed consent form, and are willing to cooperate with follow-up.

Exclusion criteria

Exclusion criteria: 1. Recent respiratory tract infection; 2. History of chronic respiratory system diseases; 3. Severe cardiovascular, brain, liver, or kidney dysfunction; 4. Cardiac conduction block, sinus bradycardia; 5. History of smoking or drug abuse; 6. History of gastroesophageal reflux; 7. Difficult airway assessed before surgery; 8. Preoperative use of corticosteroids or analgesic drugs; 9. Allergy to dyclonine gel or its components; 10. Mental disorder, unable to communicate; 11. Refusal to participate in this study.

Design outcomes

Primary

Measure	Time frame
The condition of throat pain and hoarseness in both groups. ;Cough score during extubation in both groups.;	—

Secondary

Measure	Time frame
Record the incidence of laryngospasm or bronchospasm, hypoxemia, hypotension, hypertension, tachycardia, and nausea and vomiting during and after surgery.;Systolic blood pressure, diastolic blood pressure, heart rate, mean arterial pressure;The ages, BMIs, ASA classifications, Mallampati airway classifications, tracheal intubation times, surgical durations, anesthetic durations, tracheal tube retention times, and extubation times of the two groups of patients.;	—

Measure

Time frame

Record the incidence of laryngospasm or bronchospasm, hypoxemia, hypotension, hypertension, tachycardia, and nausea and vomiting during and after surgery.;Systolic blood pressure, diastolic blood pressure, heart rate, mean arterial pressure;The ages, BMIs, ASA classifications, Mallampati airway classifications, tracheal intubation times, surgical durations, anesthetic durations, tracheal tube retention times, and extubation times of the two groups of patients.;

—

Countries

China

Contacts

Public ContactLongsheng Zhang

Jieyang People's Hospital

zhangls@gdmu.edu.cn+86 139 2560 3360

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026