Treatment-resistant depression
Conditions
Interventions
Nonconvulsive electrotherapy group:Nonconvulsive electrotherapy
Healthy control group:None
Sponsors
the Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for TRD Patients: ?Meets the DSM-V diagnostic criteria for depression through the Structured Clinical Interview for DSM Disorders (SCID); ?Meets the TRD criteria: ineffective treatment with at least two different classes of antidepressants at adequate dosage and duration; ? Age between 18 and 45 years, right-handed; ?At least a junior high school education, IQ > 70; ?HAMD-17 total score = 24 points; ?Both the patient and the guardian have completed the informed consent process. Inclusion Criteria for the Healthy Control Group: ?Matched with the subjects mentioned above in terms of age, gender, and educational level. ?No family history of psychiatric disorders. ?Does not meet the diagnostic criteria for any psychiatric disorders based on SCID-IV screening. ?The subject has signed an informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for TRD Patients: ?Meets the DSM-IV Axis I diagnostic criteria for other psychiatric disorders; ?Currently has severe physical or neurological diseases; ?Has a history of stimulant, narcotic, or sedative-hypnotic drug dependence; ?Concurrently taking other medications that affect the evaluation of treatment efficacy, such as neuroleptics; ?Women who are pregnant or breastfeeding; ?Those with contraindications for MEG or MRI scans; ?Considered unsuitable for ketafol anesthesia ECT treatment by the attending physician, such as those allergic to esketamine. Exclusion Criteria for the Healthy Control Group: ?Contraindications for MEG or MRI scanning. ?Current severe physical or neurological diseases. ?Women who are pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Remission rate;Neurocognitive function; | — |
Countries
China
Contacts
Public ContactZheng Wei
the Affiliated Brain Hospital of Guangzhou Medical University,
Outcome results
None listed