Digestive Tract Disease
Conditions
Interventions
group PA propofol2mg/Kg:No drug was given before induction of anesthesia, and 5ug/kg of alfentanil was slowly injected during induction of anesthesia, followed by a slow injection of the correspondin
group RA1 remimazolam 0.15mg/Kg :No drug was given before induction of anesthesia, and 5ug/kg of alfentanil was slowly injected during induction of anesthesia, followed by a slow injection of the cor
group RA2 remimazolam 0.2mg/Kg :No drug was given before induction of anesthesia, and 5ug/kg of alfentanil was slowly injected during induction of anesthesia, followed by a slow injection of the corr
group RA3 remimazolam 0.25mg/Kg :No drug was given before induction of anesthesia, and 5ug/kg of alfentanil was slowly injected during induction of anesthesia, followed by a slow injection of the cor
Sponsors
Central Hospital Affiliated To Shandong First Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Aged 60 - 80 years; (2) 18kg/m2 <= BMI <= 28kg/m2; (3) ASA (American Society of anesthesiologists) grade II ~ III elderly patients undergoing painless gastroscopy ; (4) Before the trial, the nature, significance, possible benefits, possible inconvenience and potential danger of the trial should be understood in detail, and the research procedure should be understood and the informed consent should be signed voluntarily.
Exclusion criteria
Exclusion criteria: (1)Allergic or contraindicated to benzodiazepines, opioids, propofol and its components; (2) Severe liver and kidney dysfunction (such as elevated serum transaminases>=2.5 times the upper limit of normal values, and blood creatinine levels>=176.8 umol/L); (3)Severe dehydration and severe malnutrition; (4) Severe cardiopulmonary dysfunction (such as heart failure or chronic obstructive pulmonary disease); (5) Patients with neurological or psychiatric diseases or communication disorders before operation; (6)Long term use of opioid drugs or alcoholics; (7)Need trachea intubation general anesthesia; (8)Individuals with severe hearing, vision, intellectual disabilities, and mental illnesses; (9)Patients who refuse to continue with the trial for any reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate of first dose sedation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Repeated Administration Rate; Anesthesia induction time; Incidence of overall adverse events;Anesthesia awakening time;Patient Satisfaction; | — |
Countries
China
Contacts
Public ContactHuang Haizhen
Central Hospital Affiliated To Shandong First Medical University
Outcome results
None listed