Borderline and malignant phyllodes tumor of breast
Conditions
Interventions
Gold Standard:1. Pathological examination confirms that the lesion is a metastatic tumor.
2. For lesions that cannot obtain pathology, from an imaging perspective, persistent lesions that do not respo
Index test:18F-FAPI is a imaging agent for intravenous injection, with a dosage of 0.8-1.5mCi/kg. Within 45-60 minutes after administration, PET-CT (which is a routine equipment in the hospital and do
Sponsors
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Female patients aged 18 to 75; 2. Diagnosed as borderline or malignant PT patient after puncture or partial resection biopsy; 3. Clinical laboratory tests (liver, kidney, and blood) within normal range, or abnormal without clinical significance Meaning (NCS), or abnormalities with clinical significance (CS), but do not affect PET-CT imaging, biopsy, or the implementation of surgery; 4. The Eastern Oncology Collaborative Group (ECOG) scale scores physical fitness = 0-2 points; 5. According to the guidelines of the Clinical Research Ethics Committee, provide an informed consent form (by participants, parents, or legal representatives) patients who have been signed and agreed by the designated representative.
Exclusion criteria
Exclusion criteria: 1. Severe diseases that combine non malignant tumors will affect patient compliance or put patients at risk state; 2. Pregnant or breastfeeding female patients; 3. Allergies to imaging agents and drugs; 4. Dementia, intellectual disabilities, or any mental illness that hinders the understanding of informed consent forms; 5. Claustrophobia or other mental illnesses that affect PET-CT examination; 6. The researchers believe that it is not suitable to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 18F-FAPI-42 PET-CT detection rate (sensitivity); | — |
Secondary
| Measure | Time frame |
|---|---|
| 18F-FAPI-42 PET-CT specificity;18F-FDG PET-CT sensitivity;18F-FDG PET-CT specificity;SUV value of the lesion (standard uptake value of imaging drugs by the lesion);The expression fibroblast activating protein (FAP) in the lesion; | — |
Countries
China
Contacts
Public ContactYan Nie
SunYat-Sen Memorial Hospital, SunYat-Sen University
Outcome results
None listed