Respiratory diseases
Conditions
Interventions
Group MAP:Midazolam 0.045mg/kg + Afentanil 18mg/kg+ propofol titrated to the target sedation depth
Group RAP:Remazolam 0.135mg/kg+ afentanil 18mg/kg+ propofol titrated to the target sedation depth
Group RA:Ramazolam 0.135mg/kg+ afentanil 18mg/kg+ ramazolam titrated to target sedation depth
Sponsors
Beilun People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age range between 60-85 years; 2. ASA grade I-III; 3. No other serious systemic comorbidities; 4. Be conscious and able to cooperate with the examination and treatment; 5. The patient gives informed consent and signs a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. ASA classification greater than grade III; 2. Perennial alcoholism, long-term use of drugs affecting mental status (e.g., sedatives) and monoamine oxidase inhibitors; 3. Comorbid severe liver dysfunction (e.g. Child-Pugh class C) or abnormal renal function (e.g. preoperative dialysis); 4. Comorbid psychiatric or psychological disorders resulting in impaired cognitive function; 5. Those with bronchial asthma, respiratory depression and myasthenia gravis and hypersensitivity; 6. Cardiac arrhythmia, preoperative left ventricular ejection fraction less than 30%, sick sinus node syndrome, severe sinus bradycardia (< 50 beats/minute) or atrioventricular block of degree II and above with pacemaker.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score of cough response;Sedation success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| mean arterial pressure;heart rate;Pulse oxygen saturation;end-expiratory carbon dioxide (ECO2);operator satisfaction;recall of intraoperative pain at postoperative follow-up;extra sleep after surgery;Patient satisfaction;Patient's willingness to be re-examined; | — |
Countries
China
Contacts
Public ContactWu Qiuyue
Beilun People's Hospital
Outcome results
None listed